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Abstract
Grant Number: 1R43EY11823-01A1 PI Name: HANG, JIM PI Title: Project Title: OPTICAL OCULAR OXYGEN SENSOR Abstract: This Small Business Innovation Research Phase I program will test a novel method for non-invasively measuring retinal oxygen distribution in the human eye, and has particular application in the diagnosis and treatment of some of the world's most prevalent eye diseases. There is currently no method or devise for measuring human retinal oxygen levels. It has been a great challenge to provide early diagnosis and treatment of may retinal diseases. New Dimension Research proposes a novel method that can provide real-time mapping of retinal oxygen distribution, and can be incorporated into either a digital fundus camera or a scanning laser ophthalmoscope. If successful this method would become a valuable addition to eye examination procedures. The approach can be engineered for used with phase-modulated spectroscope. The modulation technique guarantees rapid time response, signal stability, and noise rejection. PROPOSED COMMERCIAL APPLICATIONS: This device will enable ophthalmologists to determine retinal oxygen levels accurately. One objective of this effort is to detect the location of the hypoxic area of the retina in order to apply the laser beam exclusively there. This procedure would be more selective, more effective, and would result in fewer side effects than current procedures.
Thesaurus Terms:
Time-resolved, phase shift, fluorescence, quenching, oxygen deficiency and retina, diabetic.
Institution: NEW DIMENSION RESEARCH & INSTRUMENT 400 WEST CUMMINGS PARK, SUITE 3000 WOBURN, MA 01801 Fiscal Year: 1998 Award Total: $99,999 Project Start: 04-JUN-98 Project End: 03-DEC-99 ICD: NATIONAL EYE INSTITUTE IRG: ZRG1